Florida Trim Clinic · Education & Evidence
Each link below identifies the topic it supports. Sources describe their own research or educational guidance, not Florida Trim Clinic’s services or patient outcomes. Their inclusion does not imply endorsement, affiliation or sponsorship.
PubMed / Frontiers in Aging Neuroscience
A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NADSupports: NAD+ metabolism during an intravenous infusion pilot, not demonstrated benefits for energy, weight loss, cognition, addiction recovery or longevity.
PubMed / Pharmaceuticals
Clinical Evidence for Targeting NAD TherapeuticallySupports: The limited and heterogeneous clinical evidence for NAD interventions and the need for further adequately powered trials.
U.S. Food and Drug Administration
Compounding and the FDA: Questions and AnswersSupports: What compounding means, when it may address a patient's medical need, and how it differs from FDA drug approval.
Grant R, Berg J, Mestayer R, et al. Frontiers in Aging Neuroscience. 2019.
Research published in Frontiers in Aging Neuroscience reported changes in NAD+ metabolites during an intravenous infusion pilot. It did not establish clinical anti-aging, cognitive or weight-loss benefits.
Radenkovic D, Reason, Verdin E. Pharmaceuticals (Basel). 2020.
Research published in Pharmaceuticals reported limited clinical evidence across different NAD-related interventions and a need for further trials. Findings about oral precursors or laboratory mechanisms cannot be assumed to demonstrate benefits of NAD+ injections or infusions.
Florida Trim Clinic’s educational information is general and is not individualized medical advice. Prescription treatment requires evaluation by a licensed provider. Eligibility, medication selection and dosing depend on individual circumstances.
Compounded drugs are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness or quality before marketing.
Compounded products are not FDA-approved versions of brand-name drugs, and clinical trials of approved products do not establish equivalent safety or effectiveness for compounded products. FDA registration of a facility is not FDA approval of its compounded medicines. FDA advises compounded drugs should only be used for patients whose medical needs cannot be met by an FDA-approved drug. Availability and prescribing are subject to applicable law and individual provider evaluation.
For compounded GLP-1 medicines, FDA has reported dosing errors and product-quality concerns. Semaglutide sodium and semaglutide acetate are different active ingredients from the one in approved medicines. Follow the licensed provider’s and dispensing pharmacy’s instructions; discuss dosing, storage and any adverse effects with them. Read FDA’s current compounded GLP-1 safety information.
Our Origin
South Florida Trim Clinic in Naples was the first location and the origin of the Trim Clinic Network. It started with licensed medical providers, personalized care, and no membership fees, ever.
Prescription care requires an evaluation by a licensed provider, and treatment is offered only where it is clinically appropriate and you are eligible.